Infection and drug resistance · 2025
Distribution and Antibiotic Resistance Analysis of Bloodstream Infection Pathogens in Yibin, Sichuan.
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Zhou Xiangtian, Hu Rong, Xia Yuehua, Li Xu, Nie Shuangquan, Li Tindong, Chen Chao, Qi Bangdong, Li Wenquan
Аннотация
PURPOSE: To determine the distribution and antimicrobial resistance patterns of bloodstream infection (BSI) pathogens in Yibin, China, and to provide evidence for optimizing local empirical therapy and infection-control strategies.
METHODS: A retrospective study was performed on 4431 non-duplicate bloodstream isolates recovered from 32569 patients at Yibin Second People's Hospital between January 2017 and December 2024. Organisms were identified and tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion or VITEK-2 Compact. Antibiotic resistance to selected agents (eg polymyxins, vancomycin) were evaluated by broth micro-dilution and analysed based on CLSI M100-S34.
RESULTS: Gram-negative bacteria became the dominant isolates (51.4%), with their proportion significantly increasing during the study period. The main pathogens were Escherichia coli (27.4%), coagulase-negative Staphylococci (CoNS, 20.4% combined), and Klebsiella pneumoniae (9.7%). Among Enterobacteriaceae, ESBL-producing E. coli was highly prevalent (63.6%), and carbapenem-resistant K. pneumoniae (CRKP) emerged at 8.7%. Critically, Acinetobacter baumannii showed extensive drug resistance, with carbapenem resistance at 62.1-65.3% and carbapenem-resistant isolates (CRAB) exhibiting >70% resistance to most tested agents. Among Gram-positive pathogens, while methicillin resistance in CoNS was high (78%), no resistance to vancomycin or linezolid was detected in any Staphylococcus or Enterococcus isolate.
CONCLUSION: Bloodstream infections in Yibin are increasingly dominated by Gram-negative organisms, with ESBL-producing E. coli and multidrug-resistant A. baumannii posing critical therapeutic challenges. Continuous local surveillance and antimicrobial stewardship are imperative to optimize empirical therapy and improve patient outcomes.
METHODS: A retrospective study was performed on 4431 non-duplicate bloodstream isolates recovered from 32569 patients at Yibin Second People's Hospital between January 2017 and December 2024. Organisms were identified and tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion or VITEK-2 Compact. Antibiotic resistance to selected agents (eg polymyxins, vancomycin) were evaluated by broth micro-dilution and analysed based on CLSI M100-S34.
RESULTS: Gram-negative bacteria became the dominant isolates (51.4%), with their proportion significantly increasing during the study period. The main pathogens were Escherichia coli (27.4%), coagulase-negative Staphylococci (CoNS, 20.4% combined), and Klebsiella pneumoniae (9.7%). Among Enterobacteriaceae, ESBL-producing E. coli was highly prevalent (63.6%), and carbapenem-resistant K. pneumoniae (CRKP) emerged at 8.7%. Critically, Acinetobacter baumannii showed extensive drug resistance, with carbapenem resistance at 62.1-65.3% and carbapenem-resistant isolates (CRAB) exhibiting >70% resistance to most tested agents. Among Gram-positive pathogens, while methicillin resistance in CoNS was high (78%), no resistance to vancomycin or linezolid was detected in any Staphylococcus or Enterococcus isolate.
CONCLUSION: Bloodstream infections in Yibin are increasingly dominated by Gram-negative organisms, with ESBL-producing E. coli and multidrug-resistant A. baumannii posing critical therapeutic challenges. Continuous local surveillance and antimicrobial stewardship are imperative to optimize empirical therapy and improve patient outcomes.