Internal medicine (Tokyo, Japan) · 2023
Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sumi Toshiyuki, Takeda Kazuya, Michimata Haruhiko, Nagayama Daiki, Koshino Yuta, Watanabe Hiroki, Yamada Yuichi, Kodama Kentaro, Nishikiori Hirotaka, Chiba Hirofumi
Аннотация
Pneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.