Frontiers in veterinary science · 2025
Serum 25(OH)D reflects clinical characterization in dogs with chronic enteropathies.
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Vecchiato Carla Giuditta, Bardhi Anisa, Tardo Antonio Maria, Foietta Lorenzo, Biagi Giacomo, Sabetti Maria Chiara, Fracassi Federico, Barbarossa Andrea, Pietra Marco
Аннотация
INTRODUCTION: In canine chronic enteropathies (CE) and protein-losing enteropathy (PLE), vitamin D deficiency is recognized as a negative prognostic factor, while 25(OH)D status in relation to other clinical phenotypes has been poorly investigated.
METHODS: This study aimed to describe differences in CE dogs according to their response to treatment and to reveal potential associations with retrospective clinical and diagnostic data.
RESULTS: A total of 91 dogs were obtained from clinical records and categorized based on their response to treatment into the following groups: food-responsive enteropathy (FRE, n = 39), microbiota-related modulation-responsive enteropathies (MrMRE, n = 26), immunosuppressant-responsive enteropathy (IRE, n = 16), and PLE (n = 10). 25(OH)D, determined by UHPLC-MS/MS from stored serum samples, differed significantly among groups (p < 0.001). Median levels were markedly lower in the PLE group (10.3 ng/mL; range 10-27) than in FRE (33 ng/mL; 10-68) and MrMRE (37 ng/mL; 10-61) groups (p < 0.001). IRE group (20 ng/mL; 10-43) also showed reduced concentrations relative to FRE and MrMRE (p = 0.006). A multivariable linear regression model obtained using data from 75/91 dogs, revealed that fructosamine and phosphorus were positively associated with 25(OH)D status, while increased c-reactive protein was associated with a lower 25(OH)D.
CONCLUSION: In CE dogs, 25(OH)D is negatively affected by inflammation and reflects the severity of clinical characteristics and serum protein-related biomarkers.
METHODS: This study aimed to describe differences in CE dogs according to their response to treatment and to reveal potential associations with retrospective clinical and diagnostic data.
RESULTS: A total of 91 dogs were obtained from clinical records and categorized based on their response to treatment into the following groups: food-responsive enteropathy (FRE, n = 39), microbiota-related modulation-responsive enteropathies (MrMRE, n = 26), immunosuppressant-responsive enteropathy (IRE, n = 16), and PLE (n = 10). 25(OH)D, determined by UHPLC-MS/MS from stored serum samples, differed significantly among groups (p < 0.001). Median levels were markedly lower in the PLE group (10.3 ng/mL; range 10-27) than in FRE (33 ng/mL; 10-68) and MrMRE (37 ng/mL; 10-61) groups (p < 0.001). IRE group (20 ng/mL; 10-43) also showed reduced concentrations relative to FRE and MrMRE (p = 0.006). A multivariable linear regression model obtained using data from 75/91 dogs, revealed that fructosamine and phosphorus were positively associated with 25(OH)D status, while increased c-reactive protein was associated with a lower 25(OH)D.
CONCLUSION: In CE dogs, 25(OH)D is negatively affected by inflammation and reflects the severity of clinical characteristics and serum protein-related biomarkers.