Children (Basel, Switzerland) · 2025
The Essential Role of Vitamin D in Pediatric Health: Implications for Oropharyngeal Infections and Neutropenia-Associated Vulnerability.
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Manole Felicia, Ghitea Evelin Claudia, Ghitea Marc Cristian, Ghitea Timea Claudia, Manole Alexia
Аннотация
BACKGROUND/OBJECTIVE: Adequate serum vitamin D levels are essential for overall health, particularly in preventing oropharyngeal infections. This study aims to explore the relationship between serum vitamin D (25(OH)D3) levels and the prevalence of oropharyngeal diseases-specifically rhinosinusitis, otitis media, and nasopharyngitis-in patients at a private specialist medical clinic.
MATERIALS AND METHODS: The study involved 311 patients with an average age of 15.96 ± 15.06 years. Statistical analyses, including Student's t-test and chi-square test, were conducted to evaluate the significance of the findings.
RESULTS: Nasopharyngitis was highly prevalent, affecting 83.27% of participants, with higher recurrence rates in those with lower vitamin D levels (p = 0.001). Otitis media was present in 53.37% of cases, while rhinosinusitis was less common and more frequently associated with higher vitamin D levels. Patients with behavioral disorders had significantly higher mean vitamin D levels (34.82 ng/mL ± 11.85) compared to those without (28.49 ng/mL ± 14.37) (p = 0.001).
CONCLUSIONS: A subgroup of children with neutropenia (ANC < 1500/μL) exhibited significantly lower vitamin D levels and higher infection recurrence rates, underscoring their heightened vulnerability. This study highlights the importance of maintaining optimal vitamin D levels for pediatric health and suggests that higher vitamin D levels may reduce the risk of oropharyngeal infections.
MATERIALS AND METHODS: The study involved 311 patients with an average age of 15.96 ± 15.06 years. Statistical analyses, including Student's t-test and chi-square test, were conducted to evaluate the significance of the findings.
RESULTS: Nasopharyngitis was highly prevalent, affecting 83.27% of participants, with higher recurrence rates in those with lower vitamin D levels (p = 0.001). Otitis media was present in 53.37% of cases, while rhinosinusitis was less common and more frequently associated with higher vitamin D levels. Patients with behavioral disorders had significantly higher mean vitamin D levels (34.82 ng/mL ± 11.85) compared to those without (28.49 ng/mL ± 14.37) (p = 0.001).
CONCLUSIONS: A subgroup of children with neutropenia (ANC < 1500/μL) exhibited significantly lower vitamin D levels and higher infection recurrence rates, underscoring their heightened vulnerability. This study highlights the importance of maintaining optimal vitamin D levels for pediatric health and suggests that higher vitamin D levels may reduce the risk of oropharyngeal infections.