[Importance of the eradication of the focus of infection and the synchronized correction of disturbed intestinal microflora in shigellosis patients].

The dynamic study of the characteristics of serum specific Shigella endotoxinemia was carried out in 60 patients with S.flexneri infection by EIA techniques. In addition, the level of Re-glycolipid in the blood of patients was determined in EIA with the use of Re-antibodies with the simultaneous study of the rectal microbiocenosis. The degree of dysbiotic disturbances in the intestine was found to be directly related to the levels of LPS of S.flexneri 2a O-antigens and Re-glycolipid of Gram-negative bacteria, circulating in the blood. In the presence of decompensation disturbances of intestinal microflora, delayed Shigella elimination was observed in 15% of the patients and the prolongation of clinical manifestions, in 79.2% of the patients. This investigation demonstrated the expediency of complex therapy with the use of the probiotic bifidumbacterin-forte, containing bifidobacteria adsorbed on activated carbon and capable of decreasing the level of endotoxinemia and correcting damaged microbiocenosis.