Journal of gastroenterology · 2003
A new clinicopathological entity of IgG4-related autoimmune disease.
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Kamisawa Terumi, Funata Nobuaki, Hayashi Yukiko, Eishi Yoshinobu, Koike Morio, Tsuruta Kouji, Okamoto Atsutake, Egawa Naoto, Nakajima Hitoshi
Аннотация
BACKGROUND: Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
METHODS: To investigate the pathophysiology of AIP, we immunohistochemically examined the pancreas and other organs in eight patients with AIP, and in controls, using anti-CD4-T and CD8-T cell subsets, as well as IgG4 antibodies.
RESULTS: In AIP patients, severe or moderate infiltration of IgG4-positive plasma cells associated with CD4- or CD8-positive T lymphocytes was detected in the peripancreatic tissue (6/6), bile duct (8/8), gallbladder (8/8), portal area of the liver (3/3), gastric mucosa (5/7), colonic mucosa (2/2), salivary glands (1/2), lymph nodes (6/6), and bone marrow (2/2), as well as in the pancreas (8/8). There were few IgG4-positive plasma cells at the same sites in controls.
CONCLUSIONS: These results suggest that AIP is not simply pancreatitis but that it is a pancreatic lesion involved in IgG4-related systemic disease with extensive organ involvement. We propose a new clinicopathological entity, of a systemic IgG4-related autoimmune disease in which AIP and its associated diseases might be involved. Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
METHODS: To investigate the pathophysiology of AIP, we immunohistochemically examined the pancreas and other organs in eight patients with AIP, and in controls, using anti-CD4-T and CD8-T cell subsets, as well as IgG4 antibodies.
RESULTS: In AIP patients, severe or moderate infiltration of IgG4-positive plasma cells associated with CD4- or CD8-positive T lymphocytes was detected in the peripancreatic tissue (6/6), bile duct (8/8), gallbladder (8/8), portal area of the liver (3/3), gastric mucosa (5/7), colonic mucosa (2/2), salivary glands (1/2), lymph nodes (6/6), and bone marrow (2/2), as well as in the pancreas (8/8). There were few IgG4-positive plasma cells at the same sites in controls.
CONCLUSIONS: These results suggest that AIP is not simply pancreatitis but that it is a pancreatic lesion involved in IgG4-related systemic disease with extensive organ involvement. We propose a new clinicopathological entity, of a systemic IgG4-related autoimmune disease in which AIP and its associated diseases might be involved. Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
Предметные рубрики MeSH
AgedAntigens, Differentiation, B-LymphocyteAntigens, Differentiation, T-LymphocyteAutoimmune DiseasesBile DuctsBiomarkersChronic DiseaseColonFemaleGastric MucosaHumansImmunoglobulin GImmunohistochemistryLiverLymph NodesMaleMiddle AgedPancreatitisPlasma CellsRetroperitoneal FibrosisSalivary GlandsSeverity of Illness IndexStatistics as TopicStomach