Eye (London, England) · 2026
Clinical characteristics and progression rates of geographic atrophy in an Asian population from Singapore.
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Ibrahim Farah Ni, Fan Kenric Rp, Chan Hiok Hong, Ong Charles, Sun Christopher, Sim Shaun, Tan Anna Cs, Tan Tien-En, Teo Kelvin Yc, Mathur Ranjana, Chan Choi Mun, Cheung Chui Ming Gemmy, Fenner Beau J
Аннотация
PURPOSE: To characterise geographic atrophy (GA) associated with age-related macular degeneration (AMD) and its progression rates in an Asian cohort.
METHODS: Retrospective study of 170 eyes characterising GA lesions using near infrared (NIR) and spectral domain optical coherence tomography (SD-OCT).
RESULTS: The majority of patients were Chinese (88.2%), followed by Malay (4.7%), Indian (3.5%) and Others (3.5%). Mean age at baseline was 78.4 (SD 8.2) years, with 42.9% males. Mean baseline GA area was 4.25mm2 (SD 4.25), best-corrected visual acuity 0.71logMAR units (SD 0.52) and subfoveal choroidal thickness (SFCT) 168.3 μm (SD 77.4). Multifocal GA was present in 97 (57.1%) of eyes, foveal involvement in 114 (67%) and bilateral in 42 (24.7%). Macular neovascularisation was present in the fellow eye of 48 (28.2%) patients. Mean follow-up was 4.12 (SD 2.95) years, with a mean GA progression rate of 0.98 (SD 1.26)mm2/yr (SQRT 0.22 mm/yr SQRT, SD 0.21). Bilateral disease (p = 0.005), reticular pseudodrusen (p = 0.02), larger baseline GA area (p < 0.001) and multifocal disease (p = 0.01) were independently associated with greater odds of rapid GA progression.
CONCLUSION: We evaluated AMD-associated GA in Asian patients, predominantly of Chinese descent, using NIR and SD-OCT. These findings are valuable to identify high-risk patients and guide future GA therapies in Asian populations.
METHODS: Retrospective study of 170 eyes characterising GA lesions using near infrared (NIR) and spectral domain optical coherence tomography (SD-OCT).
RESULTS: The majority of patients were Chinese (88.2%), followed by Malay (4.7%), Indian (3.5%) and Others (3.5%). Mean age at baseline was 78.4 (SD 8.2) years, with 42.9% males. Mean baseline GA area was 4.25mm2 (SD 4.25), best-corrected visual acuity 0.71logMAR units (SD 0.52) and subfoveal choroidal thickness (SFCT) 168.3 μm (SD 77.4). Multifocal GA was present in 97 (57.1%) of eyes, foveal involvement in 114 (67%) and bilateral in 42 (24.7%). Macular neovascularisation was present in the fellow eye of 48 (28.2%) patients. Mean follow-up was 4.12 (SD 2.95) years, with a mean GA progression rate of 0.98 (SD 1.26)mm2/yr (SQRT 0.22 mm/yr SQRT, SD 0.21). Bilateral disease (p = 0.005), reticular pseudodrusen (p = 0.02), larger baseline GA area (p < 0.001) and multifocal disease (p = 0.01) were independently associated with greater odds of rapid GA progression.
CONCLUSION: We evaluated AMD-associated GA in Asian patients, predominantly of Chinese descent, using NIR and SD-OCT. These findings are valuable to identify high-risk patients and guide future GA therapies in Asian populations.