Children (Basel, Switzerland) · 2026
Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 3: Impacts on Growth, Neurodevelopment & Nutrition.
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Plessas-Azurduy Phoenix, Garfinkle Jarred, Beltempo Marc, Porraccio Caroline, Lapointe Anie, Wazneh Laila, Wutthigate Punnanee, Spénard Sarah, Sbrocchi Anne Marie, Racine Marie-Brossard, Mawad Wadi, Cavallé-Garrido Tiscar, Shalish Wissam, Sant'Anna Guilherme, Altit Gabriel
Аннотация
BACKGROUND: Postnatal corticosteroids (CS) improve respiratory outcomes in preterm infants, but effects on growth and neurodevelopment remain incompletely understood.
METHODS: This third instalment of a narrative review series builds on physiologic principles to examine systemic CS consequences.
MAIN FINDINGS: We explore the interplay between growth restriction, hypoxia, and neurodevelopmental vulnerability, discussing brain imaging, metabolic disruptions, and HPA axis suppression.
CONCLUSION: This review advocates for a holistic, physiology-informed approach to optimize outcomes by integrating nutritional vulnerability with cardiorespiratory status.
METHODS: This third instalment of a narrative review series builds on physiologic principles to examine systemic CS consequences.
MAIN FINDINGS: We explore the interplay between growth restriction, hypoxia, and neurodevelopmental vulnerability, discussing brain imaging, metabolic disruptions, and HPA axis suppression.
CONCLUSION: This review advocates for a holistic, physiology-informed approach to optimize outcomes by integrating nutritional vulnerability with cardiorespiratory status.