Exploring the spatial covariance of cerebral vascular density and amyloid burden in Alzheimer's disease.
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Argenti Lucia, Cirone Alessio, Massa Federico, Sentieri Elena, Losa Mattia, Lorenzini Luigi, Garbarino Sara, Sofia Luca, Raffa Stefano, Bauckneht Matteo, Sambuceti Gianmario, Kreshpa Wendy, Bozzo Giulia, Tomassini Giulia, De Cesari Francesca, Pelagotti Virginia, Pulze Martina, Gualco Lorenzo, Hamedani Mehrnaz, Razzetta Chiara, Brugnolo Andrea, Girtler Nicola, Caneva Stefano, Mattioli Pietro, Morbelli Silvia, Ali Shahzad, Piana Michele, Serrati Carlo, Uccelli Antonio, Chincarini Andrea, Arnaldi Dario, Roccatagliata Luca, Bandini Fabio, Orso Beatrice, Pardini Matteo
Аннотация
METHODS: Seventy-four amyloid-positive AD patients underwent amyloid positron emission tomography (PET) and magnetic resonance imaging. Regional Aβ uptake was quantified; spatial associations with normative arterial (time-of-flight magnetic resonance angiography) and venous (susceptibility-weighted imaging) density maps were assessed using correlation analyses and partial least squares (PLS) regression, controlling for early-frame PET as a proxy for perfusion.
RESULTS: Higher arterial density was associated with lower Aβ uptake (r = -0.68, p < 0.001), independent of venous density and perfusion. PLS explained 71% of regional variance, highlighting temporo-limbic regions. Subject-level analyses showed heterogeneous vascular-amyloid coupling, related to education and global Aβ burden.
DISCUSSION: Arterial architecture may contribute to regional amyloid vulnerability through vascular clearance mechanisms.