LACTOSE TOLERANCE AND RISK OF MULTIFACTORIAL DISEASES ON THE EXAMPLE OF GASTROINTESTINAL TRACT AND BONE TISSUEPATHOLOGIES.

Metabolism changes play a key role in many mammalian diseases such as decreasing bone mineral density, osteoporosis, digestive disorders. Lactose intolerance is found in 75% of the in human world's population. The aim of this study was evaluation of the genetic aspects of lactase deficiency in different ethnic groups and its relation with pathologies of bone tissue and gastrointestinal tract. The world data of lactose tolerance, hip fracture incidence, digestive diseases were derived from websites the International Osteoporosis Foundation and World Health Organization. Statistical analysis was carried out by Shapiro-Wilk test, Spearman correlation. An analysis of the world population showed that the lactose tolerance parameters have a statistically significant positive correlation with the hip fractures frequency (r=0.656) and a negative correlation with digestion diseases mortality (r=-0.577). An important factor in the pathologies prevention is the diet correction taking into account the phenotype and genotype of lactose tolerance.