Zhonghua yi xue za zhi · 1998
[Changes of GABA immunoreactivity in aged rat cochlear nucleus].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yang W, Wu W, Fang Y
Аннотация
OBJECTIVES: To detect the changes of gama-aminobutyric acid (GABA) immunoreactivity in the aged rat cochlear nucleus and to investigate its relationship with the initiation of presbycusis.
METHODS: The cochlear nucleuses of adult (2-3 months) and aged (20-36 months) Wistar rats were stained with streptavidin/peroxidase (S-P) technique. GABA-positive neurons were counted with a computer-aid image analysis system.
RESULTS: Most of the GABA-immunoreactive cell bodies were found in the superficial layers of the dorsal cochlear nucleus (DCN). The number of GABA-positive neurons decreased significantly in the DCN of the aged rat cochlear nucleus (P < 0.001).
CONCLUSION: The reduction of GABA positive neurons in the aged rat cochlear nucleus may be related to presbycusis.
METHODS: The cochlear nucleuses of adult (2-3 months) and aged (20-36 months) Wistar rats were stained with streptavidin/peroxidase (S-P) technique. GABA-positive neurons were counted with a computer-aid image analysis system.
RESULTS: Most of the GABA-immunoreactive cell bodies were found in the superficial layers of the dorsal cochlear nucleus (DCN). The number of GABA-positive neurons decreased significantly in the DCN of the aged rat cochlear nucleus (P < 0.001).
CONCLUSION: The reduction of GABA positive neurons in the aged rat cochlear nucleus may be related to presbycusis.