Journal of family medicine and primary care · 2026
Bone mineral density in children and adolescents with type 1 diabetes: A case-control study from South India.
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Aleem Sayyad, Hari Kumar Kvs, Guddeti Arun, Shaikh Naseemuddin Nayeemuddin, Kumar Sanjay, Vasamsetti Sai Ramya, Sridharan Anushri, Mashetty Sravanthi
Аннотация
INTRODUCTION: Bone mineral density (BMD) is affected in diabetes, and we studied the changes in BMD in children with type 1 diabetes mellitus (T1DM) and matched controls. We also assessed the impact of diabetes duration on BMD using the Dual-energy X-ray absorptiometry (DXA).
METHODS: In this single-centre, case-control study, we included 30 children and adolescents aged between 6 and 18 years with a T1DM duration of more than 6 months and a similar number of age, sex, and puberty-matched healthy controls. All the participants underwent a detailed clinical and biochemical evaluation and the BMD was assessed by DXA. The results were analysed by appropriate statistical methods.
RESULTS: The study population (14 M: 16F) had a mean (SD) age of 11.9 (3.8) years, T1DM duration of 2.7 (2) years and HbA1c of 11.2 (2.7) percent. The BMD (gm/cm2) at total body less head (TBLH) and lumbar spine (LS) was 0.63 (0.13), 0.59 (0.15) in cases and 0.65 (0.12), 0.62 (0.15) in controls (P = 0.473), respectively. The duration of diabetes did not show significant correlation with the BMD (r = 0.328, P = 0.077). BMD is correlated positively with physical activity and negatively with screen time in both cases and controls.
CONCLUSION: Our study did not find a significant difference in BMD between children with T1DM and matched controls. However, it showed the importance of physical activity and screen time for bone health in children, irrespective of diabetes.
METHODS: In this single-centre, case-control study, we included 30 children and adolescents aged between 6 and 18 years with a T1DM duration of more than 6 months and a similar number of age, sex, and puberty-matched healthy controls. All the participants underwent a detailed clinical and biochemical evaluation and the BMD was assessed by DXA. The results were analysed by appropriate statistical methods.
RESULTS: The study population (14 M: 16F) had a mean (SD) age of 11.9 (3.8) years, T1DM duration of 2.7 (2) years and HbA1c of 11.2 (2.7) percent. The BMD (gm/cm2) at total body less head (TBLH) and lumbar spine (LS) was 0.63 (0.13), 0.59 (0.15) in cases and 0.65 (0.12), 0.62 (0.15) in controls (P = 0.473), respectively. The duration of diabetes did not show significant correlation with the BMD (r = 0.328, P = 0.077). BMD is correlated positively with physical activity and negatively with screen time in both cases and controls.
CONCLUSION: Our study did not find a significant difference in BMD between children with T1DM and matched controls. However, it showed the importance of physical activity and screen time for bone health in children, irrespective of diabetes.