Metabolism open · 2026
Clinical characteristics of fulminant type 1 diabetes mellitus following acute pancreatitis.
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Chen Yaning, Chen Yingying, Cui Jia, Lu Xingchen
Аннотация
OBJECTIVE: This study aimed to gather clinical data on fulminant type 1 diabetes mellitus (FT1DM) following acute pancreatitis and investigate its clinical characteristics.
METHODS: A comprehensive search was conducted in PubMed, Embase, Web of Science, Wanfang Database, and China National Knowledge Infrastructure. This was complemented by manual screening strategies to identify FT1DM cases following acute pancreatitis that met the inclusion and exclusion criteria. Data pertaining to demographic, clinical, and laboratory results were extracted for descriptive analysis.
RESULTS: Fifteen cases met the eligibility criteria, with a male-to-female ratio of 7:8. The average age was 36.27 ± 13.46 years, and the mean BMI was 21.17 ± 3.08 kg/m2. Four patients tested positive for glutamic acid decarboxylase antibody. The mean HbA1c level was recorded at 6.19 ± 0.82%. FT1DM occurred 6.53 ± 1.50 days after the onset of symptoms of acute pancreatitis. Four patients had a family history of diabetes. All fifteen patients received intensive insulin regimens.
CONCLUSION: A temporal association was observed between AP and subsequent FT1DM. Variations in the age of onset, positivity rate of islet-related antibodies, and diabetic family history among FT1DM patients could be attributed to different ethnic backgrounds and preceded factors.
METHODS: A comprehensive search was conducted in PubMed, Embase, Web of Science, Wanfang Database, and China National Knowledge Infrastructure. This was complemented by manual screening strategies to identify FT1DM cases following acute pancreatitis that met the inclusion and exclusion criteria. Data pertaining to demographic, clinical, and laboratory results were extracted for descriptive analysis.
RESULTS: Fifteen cases met the eligibility criteria, with a male-to-female ratio of 7:8. The average age was 36.27 ± 13.46 years, and the mean BMI was 21.17 ± 3.08 kg/m2. Four patients tested positive for glutamic acid decarboxylase antibody. The mean HbA1c level was recorded at 6.19 ± 0.82%. FT1DM occurred 6.53 ± 1.50 days after the onset of symptoms of acute pancreatitis. Four patients had a family history of diabetes. All fifteen patients received intensive insulin regimens.
CONCLUSION: A temporal association was observed between AP and subsequent FT1DM. Variations in the age of onset, positivity rate of islet-related antibodies, and diabetic family history among FT1DM patients could be attributed to different ethnic backgrounds and preceded factors.