Journal of pharmacy & bioallied sciences · 2026
Influence of the Gut Microbiome on Body Composition and Metabolic Risk in Indian Children with Type 1 Diabetes Mellitus (T1dm).
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tamhane Vaishali, Shah Nikhil, Khadilkar Anuradha V, Khadilkar Vaman V, Gondhalekar Ketan, Patwardhan Vivek, Gupta Abhishek, Bhanushali Shivang P, Shouche Yogesh, Muralidharan Shrikanth
Аннотация
INTRODUCTION: The study aims to explore the gut flora presentation among Type 1 DM children with and without metabolic risks (MR) at a tertiary care center.
MATERIALS AND METHODS: A cross-sectional, observational study was conducted on children with T1DM (n = 68, mean-age = 12.9 years, disease-duration = 5.5 years, average HbA1c = 9.8%) divided into two groups based on with (n = 35) and without (n = 33) metabolic risk factors. Clinical-history, anthropometry, biochemical investigations, and body composition analysis was performed. Stool samples were collected; DNA extraction and targeted 16srRNA gene amplicon sequencing was performed.
RESULTS: Significant differences were observed in the relative abundance of gut microbiome at the family and genera level in children with metabolic risk as compared to without metabolic risk.
CONCLUSION: Gut microbiome significantly differs in children with or without MR among T1DM cases.
MATERIALS AND METHODS: A cross-sectional, observational study was conducted on children with T1DM (n = 68, mean-age = 12.9 years, disease-duration = 5.5 years, average HbA1c = 9.8%) divided into two groups based on with (n = 35) and without (n = 33) metabolic risk factors. Clinical-history, anthropometry, biochemical investigations, and body composition analysis was performed. Stool samples were collected; DNA extraction and targeted 16srRNA gene amplicon sequencing was performed.
RESULTS: Significant differences were observed in the relative abundance of gut microbiome at the family and genera level in children with metabolic risk as compared to without metabolic risk.
CONCLUSION: Gut microbiome significantly differs in children with or without MR among T1DM cases.