Journal of cancer survivorship : research and practice · 2025
Survivors' perspectives on cisplatin-induced ototoxicity and barriers to ototoxicity monitoring.
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Lee David S, Mueller Lauren, Wong Susan K, Travis Emma Y, Munyemana Marie-Ange, Mazul Angela L, McClannahan Katrina S, Jeffe Donna B, Lieu Judith E
Аннотация
PURPOSE: Cisplatin-based chemoradiation therapy (CRT) causes ototoxicity in survivors of head and neck (H&N) cancer, but rates of audiologic follow-up are poor. Our objective is to identify (1) QOL domains that are affected by treatment-related ototoxicity and (2) barriers to ototoxicity monitoring among survivors of H&N cancer to inform patient-centered interventions that reduce undiagnosed and untreated ototoxicity in survivorship.
METHODS: A qualitative study using semi-structured focus groups was conducted from March 2023 to September 2023 on survivors of H&N cancer treated with cisplatin-based CRT at a single tertiary care center. Inductive thematic analysis was used to identify themes related to the effect of ototoxicity on QOL and barriers to ototoxicity monitoring.
RESULTS: Seven focus groups ranging from 1 to 4 participants were conducted on 18 total participants (median age = 58 (range 45-67); 13 (72%) male; 16 (89%) white). Themes regarding ototoxicity and its effects on QOL included (1) social isolation, (2) emotional distress, (3) adaptive behaviors, and (4) that the impact is context-dependent. Themes regarding barriers to ototoxicity monitoring included (5) inconsistent referral to audiology; (6) the lack of patient education; (7) socioeconomic factors; and (8) hesitancy towards hearing aids.
CONCLUSIONS: Treatment-related ototoxicity has long-term implications for poorer QOL in H&N cancer survivorship. However, the negative impact of ototoxicity changes over time and depends on multiple patient-related factors.
IMPLICATIONS FOR CANCER SURVIVORS: Monitoring programs might seek to develop protocols to routinely screen H&N cancer survivors for ototoxicity and provide referrals and patient education material to improve audiologic follow-up. Such protocols may decrease rates of undiagnosed and untreated hearing loss in this patient population.
METHODS: A qualitative study using semi-structured focus groups was conducted from March 2023 to September 2023 on survivors of H&N cancer treated with cisplatin-based CRT at a single tertiary care center. Inductive thematic analysis was used to identify themes related to the effect of ototoxicity on QOL and barriers to ototoxicity monitoring.
RESULTS: Seven focus groups ranging from 1 to 4 participants were conducted on 18 total participants (median age = 58 (range 45-67); 13 (72%) male; 16 (89%) white). Themes regarding ototoxicity and its effects on QOL included (1) social isolation, (2) emotional distress, (3) adaptive behaviors, and (4) that the impact is context-dependent. Themes regarding barriers to ototoxicity monitoring included (5) inconsistent referral to audiology; (6) the lack of patient education; (7) socioeconomic factors; and (8) hesitancy towards hearing aids.
CONCLUSIONS: Treatment-related ototoxicity has long-term implications for poorer QOL in H&N cancer survivorship. However, the negative impact of ototoxicity changes over time and depends on multiple patient-related factors.
IMPLICATIONS FOR CANCER SURVIVORS: Monitoring programs might seek to develop protocols to routinely screen H&N cancer survivors for ototoxicity and provide referrals and patient education material to improve audiologic follow-up. Such protocols may decrease rates of undiagnosed and untreated hearing loss in this patient population.