2-Hydroxyethyl methacrylate (2-HEMA) sensitization, a global epidemic at its peak in Spain?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Gatica-Ortega Maria Elena, Pastor-Nieto Maria Antonia, Giménez-Arnau Ana María, Mercader-García Pedro, Sanz-Sánchez Tatiana, Carrascosa-Carrillo José Manuel, Córdoba-Guijarro Susana, Sánchez-Pérez Javier, Silvestre Juan Francisco, Frutos Francisco Javier Ortiz-de, Tous-Romero Fátima, Fernández-Redondo Virginia, Serra-Baldrich Esther, Ruíz-González Inmaculada, González Pérez Ricardo, Miquel-Miquel Javier, Guillén Paloma Sánchez-Pedreño, Hervella-García Marcos, Heras-Mendaza Felipe, Gómez-de-la-Fuente Enrique, Zaragoza-Ninet Violeta, Gilo Araceli Sánchez, Rodríguez-Serna Mercedes, Melé-Ninot Gemma, Descalzo Miguel Ángel, de-Vega Marina, García-Doval Ignacio, Borrego Leopoldo
Аннотация
OBJECTIVES: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.
METHODS: From January 2019 to December 2022, 2-HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.
RESULTS: Six thousand one hundred thirty-four patients were consecutively patch tested with 2-HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable 'occupational' was found to be significantly associated with a higher risk for relevant positive reactions to 2-HEMA (OR: 10.9; 95% CI: 8.1-14.9).
CONCLUSION: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2-HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.