International journal of developmental disabilities · 2024
Serum Zonulin, Claudin-5, junction Adhesion Molecule-A, Occludin and Tricellulin levels in children with autism spectrum disorder.
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Eroğlu Havvanur, Işık Ümit, Büyükbayram Halil İbrahim, Arıcan Hülya Mete
Аннотация
INTRODUCTION: The aim of this study is to determine whether there is a difference in serum Zonulin, Occludin, Claudin-5, Junctional Adhesion Molecule-A (JAM-A), Tricellulin levels between individuals diagnosed with Autism Spectrum Disorder (ASD) and healthy controls.
METHOD: A total of 40 children with ASD and 40 controls aged 2-12 years were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits. Childhood Autism Rating Scale, Autism Behavior Checklist and Aberrant Behavior Checklist were applied to determine the severity of autistic symptoms.
RESULTS: Serum Zonulin, Occludin, Claudin-5, Tricellulin and JAM-A levels did not differ between the study and control groups. There was no relationship between the severity of ASD symptoms and biochemical parameters.
DISCUSSION: Although the findings of the study suggest that the permeability of the Blood Brain Barrier (BBB) is not effective in the etiology of ASD, there is a need for new studies addressing the limitations of our study in a larger and heterogeneous sample in order to generalize the findings.
METHOD: A total of 40 children with ASD and 40 controls aged 2-12 years were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits. Childhood Autism Rating Scale, Autism Behavior Checklist and Aberrant Behavior Checklist were applied to determine the severity of autistic symptoms.
RESULTS: Serum Zonulin, Occludin, Claudin-5, Tricellulin and JAM-A levels did not differ between the study and control groups. There was no relationship between the severity of ASD symptoms and biochemical parameters.
DISCUSSION: Although the findings of the study suggest that the permeability of the Blood Brain Barrier (BBB) is not effective in the etiology of ASD, there is a need for new studies addressing the limitations of our study in a larger and heterogeneous sample in order to generalize the findings.