Медицинская библиотека · Current molecular medicine · 2019

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.

Zhu Jiangli, Zhang Jing, Wang Yan, Chen Jianping, Li Xiaopeng, Liu Xiangling, Kong Eryan, Su Shao B, Zhang Zhongjian

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

BACKGROUND

Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

METHODS

In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

RESULTS

The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.

CONCLUSION

The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Для цитирования: Zhu Jiangli, Zhang Jing, Wang Yan, Chen Jianping, Li Xiaopeng, Liu Xiangling, Kong Eryan, Su Shao B, Zhang Zhongjian. The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.. Current molecular medicine. 2019. DOI: 10.2174/1566524019666190627122655.

Предметные рубрики MeSH

Administration, Topical Animals Cell Movement Cells, Cultured Corneal Neovascularization Cytokines Endothelial Cells Humans Interleukin-1 Keratitis Mice Mice, Inbred C57BL Real-Time Polymerase Chain Reaction Recombinant Proteins Retina Sodium Hydroxide Vascular Endothelial Growth Factor A

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.