Bratislavske lekarske listy · 2010
Protective effects of propofol on peritoneal adhesions in cecal ligation and puncture model.
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Aykas Ahmet, Yuzbasioglu Mehmet Fatih, Kurutas Ergul Belge, Nart Ahmet, Demirtas Ozgur, Dogan Murat, Oksuz Hafize, Simsek Cenk
Аннотация
AIM: We assumed that one of the most widely used anesthetic agents, propofol, which is the most widely used anesthetic for sedation, may reduce inflammatory processes and organ injury induced by cecal ligation and puncture.
STUDY DESIGN: Bacterial peritonitis was induced in 18 rats by cecal ligation and puncture. The rats were randomly assigned to three groups. Group 1 (n=6) received propofol, group 2 (n=6) received intralipid, group 3 (n=6) was a control group, which did not receive any injection. All animals were killed 14 days later so we could assess the adhesion score. Tissue antioxidant levels were measured in 1-g tissue samples taken from the abdominal wall.
RESULTS: The adhesion score was significantly lower in the propofol group than in the control group (p<0.05). The catalase levels were higher in the intralipid and control groups than the propofol groups.
CONCLUSIONS: Intraperitoneal propofol reduced the formation of postoperative intra-abdominal adhesions without compromising wound healing in this bacterial peritonitis rat model. Propofol also decreased the oxidative stress during peritonitis (Tab. 1, Fig. 5, Ref. 28). Full Text (Free, PDF) www.bmj.sk.
STUDY DESIGN: Bacterial peritonitis was induced in 18 rats by cecal ligation and puncture. The rats were randomly assigned to three groups. Group 1 (n=6) received propofol, group 2 (n=6) received intralipid, group 3 (n=6) was a control group, which did not receive any injection. All animals were killed 14 days later so we could assess the adhesion score. Tissue antioxidant levels were measured in 1-g tissue samples taken from the abdominal wall.
RESULTS: The adhesion score was significantly lower in the propofol group than in the control group (p<0.05). The catalase levels were higher in the intralipid and control groups than the propofol groups.
CONCLUSIONS: Intraperitoneal propofol reduced the formation of postoperative intra-abdominal adhesions without compromising wound healing in this bacterial peritonitis rat model. Propofol also decreased the oxidative stress during peritonitis (Tab. 1, Fig. 5, Ref. 28). Full Text (Free, PDF) www.bmj.sk.