American journal of surgery · 2002
The structure of a biomaterial rather than its chemical composition modulates the repair process at the peritoneal level.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Bellón Juan M, Jurado Francisca, García-Honduvilla Natalio, López Raquel, Carrera-San Martín Antonio, Buján Julia
Аннотация
BACKGROUND: This study was designed to establish whether the spatial structure of a prosthesis conditions its behavior at the peritoneal level.
METHODS: Abdominal defects comprising all the wall (except skin) were created in rabbits and repaired with a laminar (DM) or reticular (CV-4) ePTFE-prosthesis. Fourteen days postimplant, specimens were obtained for scanning electron and light microscopy. Peritoneal adhesions, resistance to traction, and neoperitoneum thickness were quantified.
RESULTS: Adhesions to CV-4 were firm and integrated within surrounding tissue; only scarce adhesion formation was observed for DM. Adhesion area was significantly greater (P <0.01) in the CV-4 than in DM (7.00 +/- 2.6; 0.15 +/- 0.08 cm(2)). The neoperitoneum was organized for DM and disorganized for CV-4. This layer was significantly thicker (P <0.05) in DM than CV-4 (455 +/- 3.4; 70 +/- 3.1 microm). The CV-4 showed a greater resistance to traction than the DM (26.75 +/- 3.71; 14.11 +/- 3.71 N; P <0.05).
CONCLUSIONS: The structure of a biomaterial, rather than its chemical composition, modulates behavior at the peritoneal interface.
METHODS: Abdominal defects comprising all the wall (except skin) were created in rabbits and repaired with a laminar (DM) or reticular (CV-4) ePTFE-prosthesis. Fourteen days postimplant, specimens were obtained for scanning electron and light microscopy. Peritoneal adhesions, resistance to traction, and neoperitoneum thickness were quantified.
RESULTS: Adhesions to CV-4 were firm and integrated within surrounding tissue; only scarce adhesion formation was observed for DM. Adhesion area was significantly greater (P <0.01) in the CV-4 than in DM (7.00 +/- 2.6; 0.15 +/- 0.08 cm(2)). The neoperitoneum was organized for DM and disorganized for CV-4. This layer was significantly thicker (P <0.05) in DM than CV-4 (455 +/- 3.4; 70 +/- 3.1 microm). The CV-4 showed a greater resistance to traction than the DM (26.75 +/- 3.71; 14.11 +/- 3.71 N; P <0.05).
CONCLUSIONS: The structure of a biomaterial, rather than its chemical composition, modulates behavior at the peritoneal interface.