BMC public health · 2024
Associations between cardiac arrhythmias and cardiovascular disease incidence and all-cause mortality: the Kailuan study.
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Yang Xuemei, Geng Tingting, Peng Yinshun, Cui Liufu, Chen Shuohua, Wang Guodong, Gao Xiang, Wu Shouling
Аннотация
AIMS: Cardiac arrhythmia is a rising public health issue. The aim of this study was to determine the associations of atrial fibrillation (AF) and heart block with cardiovascular disease (CVD) incidence and all-cause mortality.
METHODS AND RESULTS: We included 141,362 participants (mean age [49.3], 80.9% men) from the Kailuan study. Arrhythmias were diagnosed through a 12-lead electrocardiograph (ECG). Mortality and CVD events were ascertained through multiple sources, including a municipal social insurance institution, hospital records, death certificates, and regular active follow-ups. During a median follow-up of 12.5 years, 18,301 total deaths and 13,208 cases of CVD were documented. The multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) comparing participants with AF to those without arrhythmia were 1.76 (1.61-1.93) for all-cause mortality, 2.11 (1.86-2.39) for CVD, 3.99 (3.33-4.79) for heart failure, and 1.56 (1.30-1.90) for stroke. Further, comparing participants with heart block to those without arrhythmia, the multivariable-adjusted HRs (95% CIs) were 1.31 (1.24-1.38) for all-cause mortality, 1.26 (1.18-1.35) for CVD, 1.40 (1.23-1.59) for heart failure, and 1.25 (1.15-1.37) for stroke. Additionally, there were generally stronger associations for AF and heart block with all-cause mortality and CVD in younger participants compared with their older counterparts (Ps-interaction ≤ 0.02) and a stronger association between AF and CVD in women compared with men (Ps-interaction ≤ 0.006).
CONCLUSION: AF and heart block were associated with a higher risk of subsequent adverse CVD events and mortality. Our findings highlight the importance of strategies for preventing cardiac arrhythmias to reduce the risk of CVD and mortality.
METHODS AND RESULTS: We included 141,362 participants (mean age [49.3], 80.9% men) from the Kailuan study. Arrhythmias were diagnosed through a 12-lead electrocardiograph (ECG). Mortality and CVD events were ascertained through multiple sources, including a municipal social insurance institution, hospital records, death certificates, and regular active follow-ups. During a median follow-up of 12.5 years, 18,301 total deaths and 13,208 cases of CVD were documented. The multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) comparing participants with AF to those without arrhythmia were 1.76 (1.61-1.93) for all-cause mortality, 2.11 (1.86-2.39) for CVD, 3.99 (3.33-4.79) for heart failure, and 1.56 (1.30-1.90) for stroke. Further, comparing participants with heart block to those without arrhythmia, the multivariable-adjusted HRs (95% CIs) were 1.31 (1.24-1.38) for all-cause mortality, 1.26 (1.18-1.35) for CVD, 1.40 (1.23-1.59) for heart failure, and 1.25 (1.15-1.37) for stroke. Additionally, there were generally stronger associations for AF and heart block with all-cause mortality and CVD in younger participants compared with their older counterparts (Ps-interaction ≤ 0.02) and a stronger association between AF and CVD in women compared with men (Ps-interaction ≤ 0.006).
CONCLUSION: AF and heart block were associated with a higher risk of subsequent adverse CVD events and mortality. Our findings highlight the importance of strategies for preventing cardiac arrhythmias to reduce the risk of CVD and mortality.