[Features of cytokines profile in various forms of systemic inflammatory response syndrome in patients with acute calculous cholecystitis].

AIM: Comparative evaluation of systemic concentration of some cytokines in various forms of SIR in patients with acute calculous cholecystitis.

MATERIAL AND

METHODS

The study included 32 patients with acute calculous cholecystitis and SIR. According to ASSR/SCCM criteria SIR 2 was in 11, SIR 3 - in 8, SIR 4 - in 7 patients, 6 patients had sepsis. Serum TNF-α, IL-6, IL-4 and IL-10 were determined prior to surgery, in 3 and 7 days postoperatively by using of ELISA.

RESULTS

There was a cytokine imbalance whose severity depended on SIR severity and presence of sepsis.

CONCLUSION

Surgical intervention on background of basis therapy does not correct cytokine imbalance. So adequate pharmacological correction is required.