Volumetric Differences of Thalamic Nuclei Are Associated With Posttrauma Psychopathology.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Steele Nick, Hussain Ahmed, Baird C Lexi, Haswell Courtney C, Sun Delin, Rangel-Jimenez Leonel, Abdallah Chadi G, Angstadt Michael, May Geoffrey, Berg Hannah, Blackford Jennifer U, Cisler Josh M, Daniels Judith K, Davenport Nicholas D, Davidson Richard J, Densmore Maria, Disner Seth G, El-Hage Wissam, Etkin Amit, Fani Negar, Frijling Jessie L, Gordon Evan M, Grupe Daniel W, Herringa Ryan J, Hudson Anna R, Jahanshad Neda, Jovanovic Tanja, King Anthony, Koch Saskia B J, Lanius Ruth, Lazarov Amit, Li Gen, Liberzon Israel, Lissek Shmuel, Lu Guangming, Manthey Antje, Maron-Katz Adi, Nawijn Laura, Nelson Steven M, Neria Yuval, Neufeld Richard W J, Nitschke Jack B, Olatunji Bunmi O, Olff Miranda, Peverill Matthew, Quidé Yann, Ravid Orren, Rakesh Gopalkumar, Ressler Kerry, Ross Marisa, Sambrook Kelly, Sierk Anika, Sponheim Scott R, Stevens Jennifer, Suarez-Jimenez Benjamin, Théberge Jean, van Rooij Sanne J H, van Zuiden Mirjam, Veltman Dick J, Vermeiren Robert R J M, Walter Henrik, Wang Li, Zhu Xi, Zhu Ye, Zilcha-Mano Sigal, Larson Christine, deRoon-Cassini Terri A, Tomas Carissa W, Fitzgerald Jacklynn M, Cotton Andrew S, O'Leary Erin N, Xie Hong, Wang Xin, Dennis Emily L, Tate David F, Cifu David X, Walker William C, Wilde Elisabeth A, Thompson Paul M, Morey Rajendra A
Аннотация
METHODS: Thalamic volumes were compared in trauma-exposed participants with PTSD (n = 238), major depressive disorder (MDD) (n = 184), and comorbid PTSD+MDD (n = 618) and in trauma-exposed control participants (n = 1018). PTSD and MDD symptom severity, PTSD symptom clusters, and childhood trauma were similarly examined for associations with thalamic volume.
RESULTS: Participants with PTSD had smaller sensorimotor thalamic nuclei, while participants with MDD or comorbid PTSD+MDD had smaller mediodorsal (MD) thalamus volumes relative to control participants. Severity of PTSD and MDD symptoms negatively correlated with MD volume. A significant interaction between PTSD and MDD severity was found, such that MDD severity was positively associated with whole thalamus volume only among individuals with high PTSD severity. We observed both positive and negative volumetric associations for specific PTSD symptom clusters and childhood trauma subtypes.
CONCLUSIONS: Whole thalamus volume and volumes of the sensorimotor and limbic thalamus may play an important role in the development of PTSD and MDD in the aftermath of trauma exposure. The interaction between PTSD and MDD symptoms and contrasting effects across PTSD symptom clusters and types of childhood adversity suggest that multiple neurobiological mechanisms are involved in shaping thalamic volume posttrauma.