European journal of heart failure · 2026
Hemodynamic changes in response to GLP-1 treatment in ICD and CRT patients: insights from HeartLogic sensor data.
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Fussing Frederik Holme, Davodian Lise Witten, Davodian Danny Witten, Johansen Niklas Dyrby, Kumarathurai Preman, Modin Daniel, Sattler Stefan, Larroudé Charlotte, Risum Niels, Vinther Michael, Køber Lars, Rossing Kasper, Ersbøll Mads, Poulsen Mikael Kjær, Løgstrup Brian Bridal, Holm Katja Fiedler, Haugan Ketil J, Chien Christopher, Claggett Brian, Solomon Scott, Fudim Marat, Hernandez Adrian, Bekfani Tarek, Johansen Jens Brock, Nielsen Jens Cosedis, Stolen Craig M, Biering-Sørensen Tor
Аннотация
BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is increasingly used, but the physiological effects in patients with heart failure and reduced ejection fraction (HFrEF) remain uncertain. Continuously collected data from implantable cardiac devices may enable evaluation of drug effects in a real-world setting.
METHODS: In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF.
RESULTS: In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38-2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65-2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17-1.15) (all P < .01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P < .01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n = 80), with no evidence of effect modification.
CONCLUSION: GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.
METHODS: In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF.
RESULTS: In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38-2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65-2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17-1.15) (all P < .01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P < .01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n = 80), with no evidence of effect modification.
CONCLUSION: GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.