Acta oto-laryngologica · 2009
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Lopez-Escamez Jose A, Moreno Antonia, Bernal Monica, Perez-Garrigues Herminio, Santos-Perez Sofia, Soto-Varela Andres, Aran Ismael, Fernandez-Sanfrancisco Omar, Lopez-Nevot Alicia, Lopez-Nevot Miguel A
Аннотация
CONCLUSION: The longer alleles (CA)17-20 of the promoter region of PARP-1 gene may confer some protection against bilateral Meniere's disease (BMD).
OBJECTIVE: To analyze microsatellite (CA)(n) polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD.
SUBJECTS AND METHODS: Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were compared with a group of 371 normal controls from the same origin in a prospective multicenter study. We developed a specific amplification protocol to determine the PARP1-promotor CA microsatellite polymorphisms.
RESULTS: We found that the longer alleles (CA)17-20 had a very low frequency in BMD (2/160, 1.3%, OR=7.33 (1.77-30.37, 95% CI), corrected p=0.012), suggesting that it may confer some protection against BMD.
OBJECTIVE: To analyze microsatellite (CA)(n) polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD.
SUBJECTS AND METHODS: Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were compared with a group of 371 normal controls from the same origin in a prospective multicenter study. We developed a specific amplification protocol to determine the PARP1-promotor CA microsatellite polymorphisms.
RESULTS: We found that the longer alleles (CA)17-20 had a very low frequency in BMD (2/160, 1.3%, OR=7.33 (1.77-30.37, 95% CI), corrected p=0.012), suggesting that it may confer some protection against BMD.
Предметные рубрики MeSH
AllelesAllelic ImbalanceGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMeniere DiseaseMicrosatellite RepeatsPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesPolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticProspective StudiesReference ValuesRepetitive Sequences, Nucleic Acid