[Applications of a rat model of chronic bronchitis on toxicity of PM2.5].

OBJECTIVE

To study the acute toxicity of PM2.5 to the rats with chronic bronchitis and the control rats and the difference between the model rats and the control rats on PM2.5 toxicity.

METHODS

With the use of an intratracheal instillation, both groups were exposed to suspensions of PM2.5. After three times, the levels of ALB, LDH, AKP, MDA and GSH in bronchoalveolar lavage fluid (BALF) were analyzed.

RESULTS

PM2.5 could induce the acute toxicity to both model rats and control rats, and dose-response relationships were observed in all indexes. In model rats, the levels of ALB, LDH, AKP, and MDA were higher in control rats( P < 0.05), while the levels of GSH were lower in control rats (P < 0.05).

CONCLUSION

PM2.5 could have acute toxic effects on both model rats and health rats, and the rats with chronic bronchitis are more susceptible to PM2.5 than health rats.