Atherosclerosis · 2012
Endothelial function and cardiovascular risk in patients with idiopathic sudden sensorineural hearing loss.
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Ciccone Marco Matteo, Cortese Francesca, Pinto Mariangela, Di Teo Concetta, Fornarelli Fara, Gesualdo Michele, Mezzina Antonia, Sabatelli Evelina, Scicchitano Pietro, Quaranta Nicola
Аннотация
OBJECTIVE: To evaluate cardiovascular risk factors and pre-clinical atherosclerosis in subjects affected by idiopathic sudden sensorineural hearing loss (ISSHL).
METHODS: In this study, 29 ISSHL patients and 29 healthy controls were evaluated. All of the patients underwent a complete audiovestibular and clinical evaluation. Carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD) of the brachial artery were assessed as early markers of atherosclerosis.
RESULTS: Our results showed that FMD was significantly lower in the ISSHL patients than in the controls (5.6 ± 1.6% vs. 7.7 ± 3.7%, p < 0.01). Moreover, the total cholesterol and low density lipoprotein cholesterol were significantly higher in the ISSHL patients than in the controls (p < 0.05). The two groups did not differ with regards to C-IMT and other cardiovascular risk factors. Vestibular involvement was shown to be associated with lower FMD values (4.1 ± 1.7% vs. 5.8 ± 1.5%, p < 0.05). No relationship was found between C-IMT and vestibular involvement. Finally, multiple logistic regression highlighted the finding that only FMD values seemed to predispose individuals to developing ISSHL (p = 0.03, OR: 1.4).
CONCLUSIONS: ISSHL seemed to be associated with vascular endothelial dysfunction and an increased cardiovascular risk, which supports the hypothesis of a vascular aetiology for this disease.
METHODS: In this study, 29 ISSHL patients and 29 healthy controls were evaluated. All of the patients underwent a complete audiovestibular and clinical evaluation. Carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD) of the brachial artery were assessed as early markers of atherosclerosis.
RESULTS: Our results showed that FMD was significantly lower in the ISSHL patients than in the controls (5.6 ± 1.6% vs. 7.7 ± 3.7%, p < 0.01). Moreover, the total cholesterol and low density lipoprotein cholesterol were significantly higher in the ISSHL patients than in the controls (p < 0.05). The two groups did not differ with regards to C-IMT and other cardiovascular risk factors. Vestibular involvement was shown to be associated with lower FMD values (4.1 ± 1.7% vs. 5.8 ± 1.5%, p < 0.05). No relationship was found between C-IMT and vestibular involvement. Finally, multiple logistic regression highlighted the finding that only FMD values seemed to predispose individuals to developing ISSHL (p = 0.03, OR: 1.4).
CONCLUSIONS: ISSHL seemed to be associated with vascular endothelial dysfunction and an increased cardiovascular risk, which supports the hypothesis of a vascular aetiology for this disease.
Предметные рубрики MeSH
AdultAgedBiomarkersBrachial ArteryCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessCase-Control StudiesChi-Square DistributionCholesterolCholesterol, LDLEarly DiagnosisEndothelium, VascularFemaleHearing Loss, SensorineuralHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPredictive Value of TestsRisk AssessmentRisk FactorsVasodilation