Revista iberoamericana de micologia · 2016
High rate of Candida deep-seated infection in patients under chronic hemodialysis with extended central venous catheter use.
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Ourives Ana Paula Jafet, Gonçalves Sarah Santos, Siqueira Ricardo Andreotti, Souza Ana Carolina Remondi, Canziani Maria Eugenia F, Manfredi Silvia Regina, Correa Luci, Colombo Arnaldo Lopes
Аннотация
BACKGROUND: Hemodialysis has been described as an important risk factor for the development of candidemia in patients suffering from chronic renal failure.
AIMS: The aim of this study was to evaluate the epidemiology of candidemia in outpatients with renal replacement therapy (RRT) by hemodialysis where the fungemia clearly represents a healthcare-associated infection.
METHODS: We retrospectively collected clinical and laboratory data from patients undergoing at least 3 months of RRT by hemodialysis who developed candidemia within 48h of hospital admission.
RESULTS: We identified 14 patients with candidemia with central venous catheters (CVC) in place for 11-277 days before developing fungemia. Deep-seated infection was documented in 6 out of 14 candidiasis cases (43%), including 5 cases of endocarditis (36%).
CONCLUSIONS: CVC in patients under RRT should be promptly replaced by fistulas and grafts to avoid bloodstream infections. Facing a case of candidemia, adequate source control and prompt initiation of antifungal therapy are mandatory to avoid morbidity and mortality.
AIMS: The aim of this study was to evaluate the epidemiology of candidemia in outpatients with renal replacement therapy (RRT) by hemodialysis where the fungemia clearly represents a healthcare-associated infection.
METHODS: We retrospectively collected clinical and laboratory data from patients undergoing at least 3 months of RRT by hemodialysis who developed candidemia within 48h of hospital admission.
RESULTS: We identified 14 patients with candidemia with central venous catheters (CVC) in place for 11-277 days before developing fungemia. Deep-seated infection was documented in 6 out of 14 candidiasis cases (43%), including 5 cases of endocarditis (36%).
CONCLUSIONS: CVC in patients under RRT should be promptly replaced by fistulas and grafts to avoid bloodstream infections. Facing a case of candidemia, adequate source control and prompt initiation of antifungal therapy are mandatory to avoid morbidity and mortality.
Предметные рубрики MeSH
AdultAgedBrazilCandidemiaCandidiasis, InvasiveCatheter-Related InfectionsCatheterization, Central VenousCentral Venous CathetersCross InfectionDisease SusceptibilityEndocarditisEndophthalmitisEye Infections, FungalFemaleHumansIncidenceMaleMiddle AgedRenal DialysisRetrospective StudiesTime FactorsYoung Adult