Optics letters · 2026
Abnormally efficient broadband near-infrared luminescence from Ba3W2O9:Mn4+ achieved through a unique lattice structure.
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Ouyang Tianzheng, Chen Yuting, Huang Chenyang, Wen Hongli, Mu Zhongfei, Guo Hai
Аннотация
OBJECTIVE: To investigate the clinical characteristics and antimicrobial resistance differences in patients with Intra-abdominal infection-associated bloodstream infection (IA-BSI) caused by Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae).
METHODS: A total of 276 patients with Intra-abdominal infection-associated bloodstream infection (IA-BSI) were retrospectively enrolled from a single center, including 185 cases in the Escherichia coli group and 91 cases in the Klebsiella pneumoniae group. The chi-square test and Mann-Whitney U-test were used to compare clinical characteristics and antimicrobial resistance profiles between the two groups, and Kaplan-Meier curves were plotted to evaluate 30-day prognosis.
RESULTS: (1) The Klebsiella pneumoniae group had higher Pitt scores, SOFA scores, and carbapenem-resistant (CR) rates (P<0.05); (2) The Escherichia coli group showed significantly higher ESBL-positive rates and quinolone resistance rates (P<0.05); (3) The CR group had higher Pitt and SOFA scores, with an inapplicability rate of empirical therapy of 90.0% and a mortality rate of 60.0%; (4) No statistically significant difference in 30-day mortality was observed between the Escherichia coli and Klebsiella pneumoniae groups (P=0.24).
CONCLUSION: There are heterogeneities in clinical characteristics and antimicrobial resistance profiles between patients with IA-BSI caused by Escherichia coli and Klebsiella pneumoniae. Patients infected with Klebsiella pneumoniae present with more severe conditions, higher carbapenem resistance rates and greater treatment difficulty, whereas Escherichia coli is characterized by high ESBL-positive rates and high quinolone resistance rates. This study provides evidence for clinical selection of antimicrobial agents, and further multicenter studies are needed for validation.
METHODS: A total of 276 patients with Intra-abdominal infection-associated bloodstream infection (IA-BSI) were retrospectively enrolled from a single center, including 185 cases in the Escherichia coli group and 91 cases in the Klebsiella pneumoniae group. The chi-square test and Mann-Whitney U-test were used to compare clinical characteristics and antimicrobial resistance profiles between the two groups, and Kaplan-Meier curves were plotted to evaluate 30-day prognosis.
RESULTS: (1) The Klebsiella pneumoniae group had higher Pitt scores, SOFA scores, and carbapenem-resistant (CR) rates (P<0.05); (2) The Escherichia coli group showed significantly higher ESBL-positive rates and quinolone resistance rates (P<0.05); (3) The CR group had higher Pitt and SOFA scores, with an inapplicability rate of empirical therapy of 90.0% and a mortality rate of 60.0%; (4) No statistically significant difference in 30-day mortality was observed between the Escherichia coli and Klebsiella pneumoniae groups (P=0.24).
CONCLUSION: There are heterogeneities in clinical characteristics and antimicrobial resistance profiles between patients with IA-BSI caused by Escherichia coli and Klebsiella pneumoniae. Patients infected with Klebsiella pneumoniae present with more severe conditions, higher carbapenem resistance rates and greater treatment difficulty, whereas Escherichia coli is characterized by high ESBL-positive rates and high quinolone resistance rates. This study provides evidence for clinical selection of antimicrobial agents, and further multicenter studies are needed for validation.