The caregiver's inventory neuropsychological diagnosis dementia (CINDD) as useful tool in differential diagnosis of dementias.

Objective: This study confirms the validity and diagnostic utility of the CINDD (Cargiver's Inventory Neuropsychological Diagnostic Dementia) in assessing cognitive status and behavioral-personality changes through informant-based questions grounded in real-life contexts. We explored the discriminative capacity of the CINDD across various dementia types. Method: We enrolled caregivers of 111 patients at their first diagnostic evaluation. The Clinical population included patients with Alzheimer's Disease (AD), behavioral Fronto-Tempoal Dementia (bvFTD), Dementia with Lewy Body (LBD), non-fluent Primary Progressive Aphasia (nfvPPA), and AD-like Mild Cognitive Impairment (MCI-AD). Patients also underwent a comprehensive neuropsychological assessment including memory, language, visuospatial, and executive function tests. Results: Each CINDD's domain demonstrated meaningful correlations with standard cognitive measures, supporting its construct validity. Notably, the Memory cluster showed strong associations with verbal memory but not with executive or language tasks, while the Language and Perception clusters aligned well with respective cognitive domains. Conversely, Executive and Personality/Behavior clusters did not show significant correlations with any of the neuropsychological measures. The Illusion/Delusion cluster, though targeting neuropsychiatric symptoms, also captured elements of cognitive disorganization seen in conditions like LBD and bvFTD. Diagnostic analyses provided robust cluster-specific cutoffs with acceptable sensitivity and specificity. Particularly, the Memory cluster effectively distinguished memory-dominant dementias (e.g. AD, MCI-AD) from language-predominant variants (e.g. nfvPPA). Conclusion: Finally, given its informant-based structure, the CINDD is especially valuable for assessing individuals with low education, illiteracy, or migrant backgrounds. We recommend its integration with traditional neuropsychological tools to enhance diagnostic accuracy in diverse clinical populations.