International archives of allergy and immunology · 2025
The Association between Tree and Weed Pollen Sensitization and Prediction Model for <italic>Artemisia</italic> Allergy in Grasslands Region of Inner Mongolia of China.
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Yang Xiaozhe, Yang Meirong, Qing Hui, Pu Xiaoyu, Wang Zhongyi, Gao Fei, Wang Xiangdong, Zhang Luo
Аннотация
INTRODUCTION: This study aimed to investigate the distribution characteristics, sensitization patterns, and potential correlation of airborne pollen allergens of physician-diagnosed pollen-induced allergic rhinitis (PiAR) patients in Ordos city in grasslands region.
METHODS: This retrospective study enrolled 234 patients with confirmed PiAR. Skin prick tests (SPT) of 12 common pollen allergens were used to detect and analyze the correlation of pollen allergens. Kendall's tau-b correlation was performed. The LASSO regression model was used to select the most important variables. Multi-adjusted logistic regression was performed to predict the risk of Artemisia sensitization.
RESULTS: Artemisia, sunflower, and lambsquarters were the top three sensitizing pollen allergens, and the highest sensitization rate was for Artemisia (72.22%). The sensitization rate of weed pollen was higher than that of tree pollen. Kendall's tau-b correlation results showed a moderate (0.4 < r < 0.6) to strong (0.6 < r < 0.8) correlation between tree- and grass-pollen allergens. Age-, sex-adjusted logistic regression showed tree (birch, green ash), weed (Japanese hop, lambsquarters, sunflower), and grass (corn) pollen allergies were risk factors for Artemisia sensitization while age was a protective factor (all p < 0.05). Multivariate logistic regression showed that sunflower (OR = 28.34 [95% CI: 6.166-130.263], p < 0.0001) and lambsquarters (OR = 3.596 [95% CI: 1.06-12.204], p = 0.0401) were risk factors for Artemisia sensitization, especially in female PiAR.
CONCLUSION: The positive correlation of SPT results indicated the co-sensitization among common pollen allergens. Sunflower was the most significant independent risk factor for Artemisia sensitization, and co-sensitization with lambsquarters would greatly increase the risk of sensitization to Artemisia.
METHODS: This retrospective study enrolled 234 patients with confirmed PiAR. Skin prick tests (SPT) of 12 common pollen allergens were used to detect and analyze the correlation of pollen allergens. Kendall's tau-b correlation was performed. The LASSO regression model was used to select the most important variables. Multi-adjusted logistic regression was performed to predict the risk of Artemisia sensitization.
RESULTS: Artemisia, sunflower, and lambsquarters were the top three sensitizing pollen allergens, and the highest sensitization rate was for Artemisia (72.22%). The sensitization rate of weed pollen was higher than that of tree pollen. Kendall's tau-b correlation results showed a moderate (0.4 < r < 0.6) to strong (0.6 < r < 0.8) correlation between tree- and grass-pollen allergens. Age-, sex-adjusted logistic regression showed tree (birch, green ash), weed (Japanese hop, lambsquarters, sunflower), and grass (corn) pollen allergies were risk factors for Artemisia sensitization while age was a protective factor (all p < 0.05). Multivariate logistic regression showed that sunflower (OR = 28.34 [95% CI: 6.166-130.263], p < 0.0001) and lambsquarters (OR = 3.596 [95% CI: 1.06-12.204], p = 0.0401) were risk factors for Artemisia sensitization, especially in female PiAR.
CONCLUSION: The positive correlation of SPT results indicated the co-sensitization among common pollen allergens. Sunflower was the most significant independent risk factor for Artemisia sensitization, and co-sensitization with lambsquarters would greatly increase the risk of sensitization to Artemisia.