Auris, nasus, larynx · 2019
A retrospective multicenter study of sublingual gland carcinoma in Japan.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kojima Tsuyoshi, Hori Ryusuke, Tanaka Shinzo, Tamaki Hisanobu, Asato Ryo, Kitamura Morimasa, Tateya Ichiro, Shinohara Shogo, Takebayashi Shinji, Maetani Toshiki, Kitani Yoshiharu, Kumabe Yohei, Ushiro Koji, Ichimaru Kazuyuki, Honda Keigo, Mizuta Masanobu, Yamada Koichiro, Omori Koichi
Аннотация
OBJECTIVE: Salivary gland carcinoma is rare among head and neck cancers. Sublingual gland carcinoma, a type of salivary gland carcinoma, is even rarer; therefore, the number of cases at a single institute is too small for sufficient evaluation of tumor characteristics. We conducted a multicenter, retrospective analysis of sublingual gland carcinomas in patients who visited 12 institutions associated with the Kyoto Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group.
METHODS: Thirteen previously untreated patients who visited the institutions between 2006 and 2015 were enrolled. The overall survival (OS) and disease-free survival (DFS) rates for all patients and by disease stage were analyzed. Statistical analyses were performed for all patients with respect to disease stage.
RESULTS: Eight of thirteen patients were diagnosed with adenoid cystic carcinoma on pathological study. A significant difference in OS rate was observed between patients with Stage I-III and Stage IV disease; however, the difference in DFS rate by disease stage was not significant.
CONCLUSION: Stage IV disease was identified as a poor prognostic factor in patients with sublingual gland carcinoma. However, even patients with Stage I-III disease experienced relatively short DFS. Distant metastasis is a serious problem among patients with sublingual gland carcinoma.
METHODS: Thirteen previously untreated patients who visited the institutions between 2006 and 2015 were enrolled. The overall survival (OS) and disease-free survival (DFS) rates for all patients and by disease stage were analyzed. Statistical analyses were performed for all patients with respect to disease stage.
RESULTS: Eight of thirteen patients were diagnosed with adenoid cystic carcinoma on pathological study. A significant difference in OS rate was observed between patients with Stage I-III and Stage IV disease; however, the difference in DFS rate by disease stage was not significant.
CONCLUSION: Stage IV disease was identified as a poor prognostic factor in patients with sublingual gland carcinoma. However, even patients with Stage I-III disease experienced relatively short DFS. Distant metastasis is a serious problem among patients with sublingual gland carcinoma.
Предметные рубрики MeSH
AdenocarcinomaAgedAged, 80 and overAntineoplastic AgentsBone NeoplasmsCarcinoma, Adenoid CysticCarcinoma, MucoepidermoidDisease-Free SurvivalFemaleHumansJapanLung NeoplasmsLymph NodesMaleMiddle AgedNeck DissectionNeoplasm InvasivenessNeoplasm StagingOtorhinolaryngologic Surgical ProceduresPrognosisRadiotherapyRadiotherapy, AdjuvantRetrospective StudiesSublingual Gland NeoplasmsSurvival Rate