Head & neck · 2013
Clinical outcomes of patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesions.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ryu In Sun, Roh Jong-Lyel, Cho Kyung-Ja, Lee Sang-wook, Choi Seung-Ho, Nam Soon Yuhl, Kim Sang Yoon
Аннотация
BACKGROUND: We compared clinical outcomes between patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesion and properly diagnosed as malignant lesion.
METHODS: The outcomes were compared between patients with benign lesion and malignant lesion (44 each) on preoperative fine-needle aspiration cytology diagnosis who underwent conservative or radical surgery.
RESULTS: Five-year lesion-free survival (DFS) rates were 86.8% for benign lesion and 76.3% for malignant lesion (p = .128). Surgical extent did not significantly affect locoregional recurrence and DFS (p = .360). Univariate analysis showed that sublingual gland tumor, positive resection margin, and extraparenchymal extension (EPE) were significantly associated with DFS (p < .05 each). On multivariate analysis, EPE remained an independent variable (p = .047, hazard ratio = 6.621, 95% confidence interval = 1.393-31.474).
CONCLUSIONS: The clinical outcomes of patients with salivary gland carcinomas misdiagnosed as benign are relatively favorable. Conservative surgery may be sufficient for patients with low-grade and T1-2 salivary gland carcinomas.
METHODS: The outcomes were compared between patients with benign lesion and malignant lesion (44 each) on preoperative fine-needle aspiration cytology diagnosis who underwent conservative or radical surgery.
RESULTS: Five-year lesion-free survival (DFS) rates were 86.8% for benign lesion and 76.3% for malignant lesion (p = .128). Surgical extent did not significantly affect locoregional recurrence and DFS (p = .360). Univariate analysis showed that sublingual gland tumor, positive resection margin, and extraparenchymal extension (EPE) were significantly associated with DFS (p < .05 each). On multivariate analysis, EPE remained an independent variable (p = .047, hazard ratio = 6.621, 95% confidence interval = 1.393-31.474).
CONCLUSIONS: The clinical outcomes of patients with salivary gland carcinomas misdiagnosed as benign are relatively favorable. Conservative surgery may be sufficient for patients with low-grade and T1-2 salivary gland carcinomas.
Предметные рубрики MeSH
Adenoma, PleomorphicAdolescentAdultAgedBiopsy, Fine-NeedleCarcinomaDiagnostic ErrorsDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeck DissectionNeoplasm Recurrence, LocalPreoperative PeriodRadiotherapy, AdjuvantSalivary Gland NeoplasmsSalivary GlandsYoung Adult