Neuro-Chirurgie · 2026
Dose-dependent neurotoxic effects of monosodium glutamate on neural tube development in chicken embryos.
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Özlü Eylem Burcu Kahraman, Akçora Dila Şener, Akar Ezgi, Akakın Dilek, Çalışaneller Arif Tarkan, Tural Selin
Аннотация
BACKGROUND: Considering the excitatory neurotransmitter role of glutamate in the central nervous system and the widespread use of monosodium glutamate (MSG) as a food additive, this study aimed to evaluate the effects of MSG on neural tube defect formation in chicken embryos.
MATERIALS AND METHODS: In this study, fertile, specific pathogen free eggs were used. Dosage calculation was based on the provisional tolerable intake of MSG of 30 mg/kg body weight per day reported in the literature. Doses were calculated as Group A: saline, Group B: 30 mg/kg, Group C: 60 mg/kg. Monosodium glutamate was dissolved in sterile distilled water to the desired concentrations.
RESULTS: The effects of MSG on neural tube development were evaluated in chicken embryos. In the control and low-dose (30 mg/kg) groups, the neural tube and notochord were largely intact, with only minor irregularities and a single neural tube defect observed. In contrast, embryos in the high-dose group (60 mg/kg) displayed neuroectodermal separation, luminal irregularities, and multiple neural tube defects with prominent openings. The difference in the incidence of neural tube defects between the groups was statistically significant (p = 0.021), indicating a dose-dependent adverse effect of MSG on neural tube development.
CONCLUSIONS: MSG, a commonly used food additive, was found to impair neural tube development in chicken embryos in a dose-dependent manner, suggesting a potential risk during early embryogenesis.
MATERIALS AND METHODS: In this study, fertile, specific pathogen free eggs were used. Dosage calculation was based on the provisional tolerable intake of MSG of 30 mg/kg body weight per day reported in the literature. Doses were calculated as Group A: saline, Group B: 30 mg/kg, Group C: 60 mg/kg. Monosodium glutamate was dissolved in sterile distilled water to the desired concentrations.
RESULTS: The effects of MSG on neural tube development were evaluated in chicken embryos. In the control and low-dose (30 mg/kg) groups, the neural tube and notochord were largely intact, with only minor irregularities and a single neural tube defect observed. In contrast, embryos in the high-dose group (60 mg/kg) displayed neuroectodermal separation, luminal irregularities, and multiple neural tube defects with prominent openings. The difference in the incidence of neural tube defects between the groups was statistically significant (p = 0.021), indicating a dose-dependent adverse effect of MSG on neural tube development.
CONCLUSIONS: MSG, a commonly used food additive, was found to impair neural tube development in chicken embryos in a dose-dependent manner, suggesting a potential risk during early embryogenesis.