Journal of the Endocrine Society · 2025
Serum Phoenixin Levels and Their Diagnostic Significance in Girls With Precocious Puberty.
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Yang Ye, Sun Jun, Yang Shuyi, Li Siqing, Zhang Jingjing, Zhu Fei, Pan Xiaoxiao, Wang Ying, Li Xiaona, Bai Hua, Luo Peiliang, Yuan Yingdi
Аннотация
CONTEXT: Phoenixin (PNX), a recently identified neuropeptide, is recognized for its role in reproduction.
OBJECTIVE: This study aims to explores serum phoenixin expression and its diagnostic value in girls with central precocious puberty (CPP).
METHODS: Girls visiting the Pediatric Endocrinology Department of Lianyungang First People's Hospital (February 2023-February 2025) were included and divided into 3 groups: CPP (n = 48), premature thelarche (PT) (n = 58), and healthy controls (NCs, n = 50). Serum phoenixin levels were measured via enzyme-linked immunosorbent assay and compared among groups. Spearman correlation analysis assessed variable relationships, and receiver operating characteristic (ROC) curves evaluated phoenixin's diagnostic value for CPP.
RESULTS: Serum PNX-14 levels of the CPP group (228.42 [193.29-277.22] pg/mL) were considerably higher relative to the PT group (192.58 [151.34-239.48] pg/mL) (P < .05), and higher serum PNX-14 levels were found in the PT group compared to the NC group (124.26 [88.78-167.49] pg/mL) (P < .05). No statistically significant differences in PNX-20 levels were found among the groups (P > .05). PNX-14 levels were positively correlated with height, weight, body mass index, bone age, uterine and ovarian volumes, and pituitary height, and negatively with sex hormone-binding globulin. ROC analysis showed an area under the curve of 0.695 for PNX-14 in identifying CPP, with a cutoff of 195.85 pg/mL (sensitivity: 75.0%; specificity: 69.0%).
CONCLUSION: Serum PNX-14 is associated with CPP and reflects growth and pubertal development. It may serve as a potential biomarker for adjunct diagnosis of CPP in girls.
OBJECTIVE: This study aims to explores serum phoenixin expression and its diagnostic value in girls with central precocious puberty (CPP).
METHODS: Girls visiting the Pediatric Endocrinology Department of Lianyungang First People's Hospital (February 2023-February 2025) were included and divided into 3 groups: CPP (n = 48), premature thelarche (PT) (n = 58), and healthy controls (NCs, n = 50). Serum phoenixin levels were measured via enzyme-linked immunosorbent assay and compared among groups. Spearman correlation analysis assessed variable relationships, and receiver operating characteristic (ROC) curves evaluated phoenixin's diagnostic value for CPP.
RESULTS: Serum PNX-14 levels of the CPP group (228.42 [193.29-277.22] pg/mL) were considerably higher relative to the PT group (192.58 [151.34-239.48] pg/mL) (P < .05), and higher serum PNX-14 levels were found in the PT group compared to the NC group (124.26 [88.78-167.49] pg/mL) (P < .05). No statistically significant differences in PNX-20 levels were found among the groups (P > .05). PNX-14 levels were positively correlated with height, weight, body mass index, bone age, uterine and ovarian volumes, and pituitary height, and negatively with sex hormone-binding globulin. ROC analysis showed an area under the curve of 0.695 for PNX-14 in identifying CPP, with a cutoff of 195.85 pg/mL (sensitivity: 75.0%; specificity: 69.0%).
CONCLUSION: Serum PNX-14 is associated with CPP and reflects growth and pubertal development. It may serve as a potential biomarker for adjunct diagnosis of CPP in girls.