Clinics (Sao Paulo, Brazil) · 2025
The association between age at menarche and depression: A systematic review and meta-analysis with meta-regression.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ghadirzadeh Erfan, Moosazadeh Mahmood, Shakeriastani Kiarash, Zarrinkamar Maryam, Gheibi Mobina, Elyasi Forouzan, Geran Mojgan
Аннотация
INTRODUCTION: The existing literature presents conflicting findings regarding the relationship between Age At Menarche (AAM) and depression. Thus, to address this gap, this systematic review and meta-analysis aimed to evaluate current evidence to clarify the association between AAM and depression.
METHODS: Medline (PubMed), Scopus, Embase, Web of Science, and Google Scholar were searched from 2000 until June 2024 to include cross-sectional, case-control, and cohort studies. The quality of the evidence was assessed using the Newcastle-Ottawa Scale (NOS) instrument. The odds ratio (OR) of depression and its 95 % Confidence Interval (95 % CI) were calculated using the random effects model and inverse variance method. The protocol is registered in PROSPERO, number CRD42024551838.
RESULTS: From a total of 2175 search records, 13 studies were included comprising 434,838 participants with NOS scores ranging from 7 to 9. The present findings showed that early menarche is associated with significantly higher odds of depression compared to both normative AAM (OR = 1.36, 95 % CI: 1.20‒1.53) and late AAM (OR = 1.52, 95 % CI 1.22‒1.90). Also, females with later menarche had lower odds of depression compared to females with normal AAM (OR = 0.91, 95 % CI 0.76‒1.09); however, this association was not statistically significant.
CONCLUSION: The present findings demonstrated that early menarche is associated with elevated odds of depression compared to females of both normative AAM and late AAM.
METHODS: Medline (PubMed), Scopus, Embase, Web of Science, and Google Scholar were searched from 2000 until June 2024 to include cross-sectional, case-control, and cohort studies. The quality of the evidence was assessed using the Newcastle-Ottawa Scale (NOS) instrument. The odds ratio (OR) of depression and its 95 % Confidence Interval (95 % CI) were calculated using the random effects model and inverse variance method. The protocol is registered in PROSPERO, number CRD42024551838.
RESULTS: From a total of 2175 search records, 13 studies were included comprising 434,838 participants with NOS scores ranging from 7 to 9. The present findings showed that early menarche is associated with significantly higher odds of depression compared to both normative AAM (OR = 1.36, 95 % CI: 1.20‒1.53) and late AAM (OR = 1.52, 95 % CI 1.22‒1.90). Also, females with later menarche had lower odds of depression compared to females with normal AAM (OR = 0.91, 95 % CI 0.76‒1.09); however, this association was not statistically significant.
CONCLUSION: The present findings demonstrated that early menarche is associated with elevated odds of depression compared to females of both normative AAM and late AAM.