The Journal of infectious diseases · 2024
Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV.
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Agrawal Priyesh, Giron Leila B, Singh Shalini, Haw Nel Jason, Goldman Aaron R, Elkaeid Mohamed, Macatangay Bernard, Palella Frank J, Alcaide Maria L, Moran Caitlin A, Kassaye Seble G, Erdmann Nathan, Chew Kara W, Floris-Moore Michelle, Chandran Aruna, Augenbraun Michael H, Sharma Anjali, Palmer Clovis, Landay Alan L, Peluso Michael J, Keshavarzian Ali, Brown Todd T, Tien Phyllis C, Abdel-Mohsen Mohamed
Аннотация
Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.