Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
Association of Chronic Rhinosinusitis and Pseudomonas Aeruginosa in Sputum of Patients With Non-Cystic Fibrosis Bronchiectasis.
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Grabauskas Titas, Brunton Amanda E, Metersky Mark L, Winthrop Kevin, Lapinel Nicole C, Solomon George M, Jakharia Kunal, Korah-Sedgwick Michelle, Geyer Alexander
Аннотация
BACKGROUND: Pseudomonas aeruginosa (P aeruginosa), Haemophilus influenzae (H influenzae), and Staphylococcus aureus (S aureus) may chronically infect bronchiectatic airways. Chronic rhinosinusitis (CRS) is common in people with bronchiectasis. Bacterial airway infection and CRS are associated with greater bronchiectasis disease severity. However, the relationship between these pathogens and CRS in people with bronchiectasis is unclear.
RESEARCH QUESTION: Is history of CRS associated with sputum positivity for P aeruginosa, S aureus, and/or H influenzae in people with bronchiectasis?
STUDY DESIGN AND METHODS: People with bronchiectasis from the U.S. Bronchiectasis and NTM Research Registry with and without physician-reported CRS were compared with respect to demographic and clinical characteristics using cross-sectional study design. Multivariable logistic regression models were used to assess the relationship between CRS and the presence of P aeruginosa, S aureus, and H influenzae in sputum.
RESULTS: Of 1352 people with bronchiectasis and known CRS status, 222 (16%) had a history of CRS. Those with CRS were more likely to have a sputum culture positive for P aeruginosa (35% CRS versus 26% non-CRS group; p=0.007), but not S aureus (13% versus 10%; p=0.21) or H influenzae (6% versus 7%; p=0.55). After adjusting for patient demographics and clinical characteristics, CRS was associated with P aeruginosa (odds ratio: 1.5; 95% confidence interval: 1.07 to 2.08).
INTERPRETATION: We report an association of history of CRS and sputum culture positivity for P aeruginosa (but not S aureus or H influenzae) in people with bronchiectasis.
RESEARCH QUESTION: Is history of CRS associated with sputum positivity for P aeruginosa, S aureus, and/or H influenzae in people with bronchiectasis?
STUDY DESIGN AND METHODS: People with bronchiectasis from the U.S. Bronchiectasis and NTM Research Registry with and without physician-reported CRS were compared with respect to demographic and clinical characteristics using cross-sectional study design. Multivariable logistic regression models were used to assess the relationship between CRS and the presence of P aeruginosa, S aureus, and H influenzae in sputum.
RESULTS: Of 1352 people with bronchiectasis and known CRS status, 222 (16%) had a history of CRS. Those with CRS were more likely to have a sputum culture positive for P aeruginosa (35% CRS versus 26% non-CRS group; p=0.007), but not S aureus (13% versus 10%; p=0.21) or H influenzae (6% versus 7%; p=0.55). After adjusting for patient demographics and clinical characteristics, CRS was associated with P aeruginosa (odds ratio: 1.5; 95% confidence interval: 1.07 to 2.08).
INTERPRETATION: We report an association of history of CRS and sputum culture positivity for P aeruginosa (but not S aureus or H influenzae) in people with bronchiectasis.