Journal of pharmacy & bioallied sciences · 2025
Efficacy of 3D-Printed Scaffolds in Guided Tissue Regeneration for Combined Endo-Perio Lesions: A Clinical and Radiographic Study.
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Parihar Anuj Singh, Nandanan Nimisha, Patadiya Hiren H, Jain Meetu, Arya Aishwarya, Laddha Rashmi, Kumar Santosh
Аннотация
BACKGROUND: Combined endo-perio lesions (CEPLs) are one of the toughest problems in clinical dentistry because of complex causative factors and multi-rooted anatomical structures. As a result, the treatment outcome using a conventional approach is often erratic and unpredictable. This study investigated the efficacy of 3D-printed scaffolds in guided tissue regeneration (GTR) for managing CEPLs, utilizing a combined clinical and radiographic assessment approach.
MATERIALS AND METHODS: This prospective clinical trial enrolled patients diagnosed with CEPLs. Following endodontic treatment, the lesions were randomly assigned to either a test group (3D-printed scaffold + GTR) or a control group (GTR alone). Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 3 months, 6 months, and 12 months postoperatively. Radiographic assessments, including bone fill and defect resolution, were performed using cone-beam computed tomography (CBCT) at the same time intervals.
RESULTS: The test group demonstrated statistically significant improvements in all clinical parameters (PD, CAL, GR) compared to the control group at all follow-up periods (P < 0.05). Radiographic analysis revealed significantly enhanced bone fill and defect resolution in the test group compared to the control group at all time points (P < 0.05).
CONCLUSION: 3d-printed scaffolds in GTR exhibited superior clinical and radiographic outcomes compared to conventional GTR alone in the treatment of CEPLs. The 3D-printed scaffolds promoted enhanced tissue regeneration and bone formation, contributing to improved periodontal healing and defect resolution.
MATERIALS AND METHODS: This prospective clinical trial enrolled patients diagnosed with CEPLs. Following endodontic treatment, the lesions were randomly assigned to either a test group (3D-printed scaffold + GTR) or a control group (GTR alone). Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 3 months, 6 months, and 12 months postoperatively. Radiographic assessments, including bone fill and defect resolution, were performed using cone-beam computed tomography (CBCT) at the same time intervals.
RESULTS: The test group demonstrated statistically significant improvements in all clinical parameters (PD, CAL, GR) compared to the control group at all follow-up periods (P < 0.05). Radiographic analysis revealed significantly enhanced bone fill and defect resolution in the test group compared to the control group at all time points (P < 0.05).
CONCLUSION: 3d-printed scaffolds in GTR exhibited superior clinical and radiographic outcomes compared to conventional GTR alone in the treatment of CEPLs. The 3D-printed scaffolds promoted enhanced tissue regeneration and bone formation, contributing to improved periodontal healing and defect resolution.