Movement disorders : official journal of the Movement Disorder Society · 2024
Substantiating the Short Burst Duration in Cortical Myoclonus.
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van der Veen Sterre, Maliepaard Amber, van der Stouwe Madelein, Dalenberg Jelle, Tuitert Inge, Elting Jan Willem J, Tijssen Marina A J
Аннотация
BACKGROUND: Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.
OBJECTIVE: This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.
METHODS: We manually identified the burst duration of 8 patients with CM, confirmed by electromyography-electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative).
RESULTS: The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.
CONCLUSION: The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.
OBJECTIVE: This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.
METHODS: We manually identified the burst duration of 8 patients with CM, confirmed by electromyography-electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative).
RESULTS: The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.
CONCLUSION: The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.