Photomedicine and laser surgery · 2013
Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study.
Клинический случайСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Gilaberte Yolanda, Aspiroz Carmen, Alejandre M Carmen, Andres-Ciriano Elena, Fortuño Blanca, Charlez Luis, Revillo Maria Jose, Hamblin Michael R, Rezusta Antonio
Аннотация
BACKGROUND: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections.
CASE REPORT: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix(®))-PDT was used without success.
METHODS: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL.
CONCLUSIONS: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.
CASE REPORT: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix(®))-PDT was used without success.
METHODS: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL.
CONCLUSIONS: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.