Squamous cell carcinoma of the pyriform sinus treated with radical radiation therapy.

This is an analysis of 54 patients with squamous cell carcinoma of the pyriform sinus treated with radical irradiation at the University of Florida between October 1964 and March 1984. There is a 2-year minimum follow-up on all patients and 85% have at least 5 years of follow-up. Patients were excluded from analysis of disease control at the primary site, neck, and/or above the clavicles if they died less than 2 years from treatment with the site(s) continuously disease-free. All patients were included in the analysis of complications and survival. The rates of local control following initial treatment with irradiation and the ultimate local control rates, including surgical salvage of irradiation failures, were as follows: T1, 8/9 and 8/9; T2, 15/20 (75%) and 18/20 (90%); T3, 2/5 and 3/5; and T4, 0/4 and 0/4. The 5-year determinate survival rates as a function of modified AJCC stage were I, 1/1; II, 3/3; III, 5/8; IVA, 7/12; and IVB, 2/8.