[The pathogenetic and clinico-diagnostic significance of changes in leukocyte migration activity in patients with shigellosis and salmonellosis].

The peripheral blood leukocyte migration activity (LMA) was studied in 134 acute dysentery patients and 129 salmonellosis patients by using the in vitro screening assay of cell migration (SACM) from microcultures, stimulated with LPS antigens from a number of enteric pathogens. At the acute period of the disease (days 1-5) in the greater part of the patients (80-90%) the specific acceleration of LMA, later followed by its inhibition, was registered in the presence of the pronounced intoxication and diarrhea syndromes, as well as the intensive circulation of specific antigens of the infective agents in the body (established by the method of the coagglutination test). The established phase fluctuations of LMA correlated with the severity and character of the infectious process. SACM was found to be highly sensitive and specific, convenient, well reproducible and having good prospects for the early diagnosis of enteric infections, including those of mixed etiology.