The journal of contemporary dental practice · 2010
Gingival enlargement in neurofibromatosis type 1: a case report and literature review.
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Mahajan Ajay, Dixit Jaya, Bhardwaj Ashu
Аннотация
AIM: The purpose of this article is to describe a rare case of neurofibromatosis1 (NF1) of the gingiva and a review of the current literature.
BACKGROUND: Neurofibromatosis1 (NF1) of the gingiva is an uncommon cause of gingival enlargement. The disease is clinically characterized by epidermal melanosis, nevi, and flabby skin or bone malformations; in addition, the lesions may undergo malignant transformation. Involvement of the gingiva with or without concurrent skin lesions has been reported only occasionally.
CASE DESCRIPTION: A 40-year-old male patient with a history of NF1 came to us with a chief complaint of enlargement of the gums. Clinical examination revealed diffuse gingival enlargement with no signs of inflammation. The characteristic skin lesions associated with NF1 were also present. A gingival specimen was sent for biopsy.
RESULTS: Based on the history, clinical, and histological findings, NF1 was established as the cause of the gingival enlargement.
SUMMARY: NF1 may affect the gingival tissue; considering the neurological complications and malignant potential, NF1 must be diagnosed early and monitored regularly.
CLINICAL SIGNIFICANCE: The clinician should be aware of clinical and histopathological findings of NF1 considering the fact that the condition has malignant potential.
BACKGROUND: Neurofibromatosis1 (NF1) of the gingiva is an uncommon cause of gingival enlargement. The disease is clinically characterized by epidermal melanosis, nevi, and flabby skin or bone malformations; in addition, the lesions may undergo malignant transformation. Involvement of the gingiva with or without concurrent skin lesions has been reported only occasionally.
CASE DESCRIPTION: A 40-year-old male patient with a history of NF1 came to us with a chief complaint of enlargement of the gums. Clinical examination revealed diffuse gingival enlargement with no signs of inflammation. The characteristic skin lesions associated with NF1 were also present. A gingival specimen was sent for biopsy.
RESULTS: Based on the history, clinical, and histological findings, NF1 was established as the cause of the gingival enlargement.
SUMMARY: NF1 may affect the gingival tissue; considering the neurological complications and malignant potential, NF1 must be diagnosed early and monitored regularly.
CLINICAL SIGNIFICANCE: The clinician should be aware of clinical and histopathological findings of NF1 considering the fact that the condition has malignant potential.