[The pathogenicity factors of Shigella studied as the bases for the design of diagnostic and prophylactic preparations].

In this work summarized data is presented on the molecular and biological characteristics of the representatives of the genus Shigella, the genetic determination of their pathogenicity factors contributing both to the initiation of the development of the infectious process and to the formation of pathological changes in the host body. The problems of the construction of live Shigella vaccines are considered, as well as the development of new diagnostic tests, based on the data on deciphering the structure and functions of pathogenicity factors which determine the invasive properties of Shigella.