Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2004
Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Roland Peter S, Rybak Leonard, Hannley Maureen, Matz Greg, Stewart Michael G, Manolidis Spiros, Friedman Rick, Weber Peter, Owens Fred
Аннотация
OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans.
STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated.
RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed.
CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.
STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated.
RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed.
CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.