Nature communications · 2021
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Doni Andrea, Parente Raffaella, Laface Ilaria, Magrini Elena, Cunha Cristina, Colombo Federico Simone, Lacerda João F, Campos António, Mapelli Sarah N, Petroni Francesca, Porte Rémi, Schorn Tilo, Inforzato Antonio, Mercier Toine, Lagrou Katrien, Maertens Johan, Lambris John D, Bottazzi Barbara, Garlanda Cecilia, Botto Marina, Carvalho Agostinho, Mantovani Alberto
Аннотация
Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance phagocytosis by neutrophils. Apcs-/- mice are defective in vivo in terms of recruitment of neutrophils and phagocytosis in the lungs. Opsonic activity of SAP is dependent on the classical pathway of complement activation. In immunosuppressed mice, SAP administration protects hosts against A. fumigatus infection and death. In the context of a study of hematopoietic stem-cell transplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive pulmonary aspergillosis. Thus, SAP is a fluid phase pattern recognition molecule essential for resistance against A. fumigatus.