European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
The prognostic value of lymphatic vessel density in squamous cell carcinoma of the tongue: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Marini Aikaterini, Zakopoulou Roubini, Ntritsos Georgios, Iliou Kalliopi, Giannousis Christos, Varvarousis Dimitrios, Kitsoulis Panagiotis, Smyris Thomas Iraklis, Asimakopoulos Asimakis, Chatzoglou Theocharis
Аннотация
PURPOSE: Squamous cell carcinoma of the tongue (TSCC) is the most common cancer of the oral cavity accounting for 25-40% of the cases. Its unfavorable prognosis is partly attributed to the high incidence of lymph node metastasis, while lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival. The purpose of this study was to conduct a systematic review and meta-analysis, that evaluates the prognostic significance of LVD regarding nodal metastasis in TSCC, focusing on intratumoral and peritumoral LVD.
METHODS: The studies included referred to patients with TSCC who underwent tumor resection and LVD was estimated via immunohistochemistry (D2-40, LYVE-1). Literature search and data extraction were performed by two independent reviewers. Hazard ratios (HRs) and mean differences were calculated using fixed-effects or random-effects models and heterogeneity was assessed via I² statistics. A total of 26 studies were identified, with 6 meeting eligibility criteria.
RESULTS: The principal outcome was the significant association between high overall LVD and increased nodal metastasis (summary mean difference: 0.85; 95% CI: 0.21, 1.49; p= 0.010, I²=77.6%). No statistically significant association was observed for intratumoral (summary HR: 0.23; 95% CI: -0.45, 0.92; p = 0.501, I²=81%) or peritumoral LVD (summary HR: 0.10; 95% CI: -0.80, 0.99; p = 0.832, I²=89.8%).
CONCLUSION: The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.
METHODS: The studies included referred to patients with TSCC who underwent tumor resection and LVD was estimated via immunohistochemistry (D2-40, LYVE-1). Literature search and data extraction were performed by two independent reviewers. Hazard ratios (HRs) and mean differences were calculated using fixed-effects or random-effects models and heterogeneity was assessed via I² statistics. A total of 26 studies were identified, with 6 meeting eligibility criteria.
RESULTS: The principal outcome was the significant association between high overall LVD and increased nodal metastasis (summary mean difference: 0.85; 95% CI: 0.21, 1.49; p= 0.010, I²=77.6%). No statistically significant association was observed for intratumoral (summary HR: 0.23; 95% CI: -0.45, 0.92; p = 0.501, I²=81%) or peritumoral LVD (summary HR: 0.10; 95% CI: -0.80, 0.99; p = 0.832, I²=89.8%).
CONCLUSION: The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.