Oral surgery, oral medicine, oral pathology and oral radiology · 2025
Proliferative verrucous leukoplakia and unifocal verrucous leukoplakia in China: a comparative retrospective cohort study.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wu Shuangshuang, Li Linman, Wang Xu, Yan Zhimin
Аннотация
OBJECTIVE: There are limited data regarding the association and differentiation between proliferative verrucous leukoplakia (PVL) and unifocal verrucous leukoplakia (UVL).
METHODS: We retrospectively recruited oral leukoplakia (OL) patients from 2010 to 2024, analyzing the demographic, clinical, histopathological features, and malignant transformation of PVL and UVL.
RESULTS: Among 1756 OL subjects, PVL and UVL accounted for 1.88% and 1.54%, respectively, sharing features like similar age of onset and high dysplasia rates (57.58% vs 55.56%). However, significant differences still existed. Gender ratios were 1:2 in PVL and 2.34:1 in UVL. PVL had lower diagnostic accuracy due to lichenoid lesions in 69.70% of patients and higher biopsy counts (2.19 vs 1.19). Malignant transformation rates were higher in PVL (27.27% vs 11.11%), occurring on the gingiva, while in UVL, it was on the buccal mucosa and tongue.
CONCLUSIONS: PVL and UVL are distinct clinical entities, highlighting the critical need for clinicians to differentiate and closely monitor both.
METHODS: We retrospectively recruited oral leukoplakia (OL) patients from 2010 to 2024, analyzing the demographic, clinical, histopathological features, and malignant transformation of PVL and UVL.
RESULTS: Among 1756 OL subjects, PVL and UVL accounted for 1.88% and 1.54%, respectively, sharing features like similar age of onset and high dysplasia rates (57.58% vs 55.56%). However, significant differences still existed. Gender ratios were 1:2 in PVL and 2.34:1 in UVL. PVL had lower diagnostic accuracy due to lichenoid lesions in 69.70% of patients and higher biopsy counts (2.19 vs 1.19). Malignant transformation rates were higher in PVL (27.27% vs 11.11%), occurring on the gingiva, while in UVL, it was on the buccal mucosa and tongue.
CONCLUSIONS: PVL and UVL are distinct clinical entities, highlighting the critical need for clinicians to differentiate and closely monitor both.