Prognostic Nomogram for Patients With Metastatic Tongue Squamous Cell Carcinoma: A SEER-Based Study.

OBJECTIVE

To construct and validate a predictive nomogram for patients with metastatic tongue squamous cell carcinoma (MTSCC).

METHODS

From 2010 to 2015, the SEER database was used to gather the clinical information of MTSCC patients. R software was used to establish a nomogram to predict the cancer-specific survival (CSS) probability of MTSCC patients. The nomogram was validated by the concordance index (C-index), the area under the receiver-operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).

RESULTS

Following screening, 284 patients were randomized, with 199 people placed in the training cohort and 85 people placed in the validation cohort, at a ratio of 7:3. By using multivariate Cox regression analysis, it was discovered that chemotherapy, lymph node dissection, brain, bone, lung metastases, and N stage were independent risk factors for CSS. The C-index was 0.664 in the training group and 0.683 in the validation group. The AUC of 1-, 3-, and 5-year CSS rates was more than 0.71, and the calibration plot further demonstrated the nomogram's strong validity. DCA showed that the nomogram had good clinical significance.

CONCLUSION

The CSS probability of patients with MTSCC can be reliably and intuitively predicted by the established nomogram model.